Publications
43. Duncan GA. "Mind the gap: Exploring extracellular spaces in the brain with particle tracking and AI ". Biophysical Journal. In Press, 2024. New & Notable Article
42. Zou H, Boboltz A, Cheema Y, Song D, Cahn D, Duncan GA. “Synthetic mucus barrier arrays as a nanoparticle formulation screening platform”. RSC Pharmaceutics. 1, 218–226, 2024. Article, Preprint
41. Boboltz A, Yang S, Duncan GA. “Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials”. Journal of Materials Chemistry B. 11, 9419-9430, 2023. Article, Preprint, Featured on Cover, Invited for "Biomaterials in Innate Immunity" themed collection
40. Yang S, Duncan GA. "Synthetic mucus biomaterials for antimicrobial peptide delivery." Journal of Biomedical Materials Research: Part A. 111 (10), 1616-26, 2023. Article, Preprint
39. Boboltz A, Kumar S, Duncan GA. “Inhaled drug delivery for the targeted treatment of asthma”. Advanced Drug Delivery Reviews. 98, 114858, 2023. Article, Selected for Emerging Voices in Drug Delivery Special Issue
38. Yeruva T, Yang S, Doski S, Duncan GA. “Hydrogels for Mucosal Drug Delivery”. ACS Applied Bio Materials. 6 (5), 1684–1700, 2023. Article
37. Zhang Y, Li S, Loch K, Duncan GA, Kaler L, Pangeni R, Peng W, Wang S, Gong X, Xu Q . “pH-responsive Mucus-penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue”. ACS Macro Letters. 12 (4), 446–453, 2023. Article
36. Cahn D, Amosu M, Maisel K, Duncan GA. “Biomaterials for intranasal and inhaled vaccine delivery”. Nature Reviews Bioengineering. 1, 83–84, 2023. Article
35. Song D, Iverson E, Kaler L, Boboltz A, Scull MA, Duncan GA. “MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium”. Science Advances. 8, eabq504, 2022. Article, Preprint
34. Cahn D, Duncan GA. "High-Density Branched PEGylation for Nanoparticle Drug Delivery". Cellular and Molecular Bioengineering. 15, 355–366, 2022. Article, Selected for Young Innovators Special Issue
33. Kaler L, Joyner K, Duncan GA. "Machine Learning Informed Prediction of Nanoparticle Mobility and Fate in the Mucus Barrier". APL Bioengineering. 6, 026103, 2022. Article, Preprint
32. Iverson E, Griswold K, Song D, Gagliardi TB, Hamidzadeh K, Kesimer M, Sinha S, Perry M, Duncan GA, Scull MA. “Membrane-Tethered Mucin 1 is Stimulated by Interferon in Multiple Cell Types and Antagonizes Influenza A Virus Infection in Human Airway Epithelium”. mBio. e01055-22, 2022. Article, Preprint
31. Kaler L, Iverson E, Bader S, Song D, Scull MA, Duncan GA. “Influenza A virus diffusion through mucus gel networks". Communications Biology, 5 (249), 2022. Article, Preprint
30. Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung J, Ignacio M, Stroka K, Duncan GA, Scull MA. “Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium”. PLOS Pathogens. 18(1), e1010159, 2022. Article, Preprint, Featured on Cover
29. Duncan GA. "Integrative approaches to enhance adeno-associated viral gene delivery". Journal of Controlled Release. 341, 44-50, 2022. Article
28. Lee BJ, Cheema Y, Bader S, Duncan GA. “Shaping nanoparticle diffusion through biological barriers to drug delivery”. JCIS Open, 100025, 2021. Article, Preprint
27. Song D, Iverson E, Kaler L, Bader S, Scull MA, Duncan GA. “Modeling airway dysfunction in asthma using synthetic mucus biomaterials”. ACS Biomaterials Science & Engineering. 7 (6), 2723–33, 2021. Article, Preprint
26. Duncan GA, J Yongsheng, Lefort MC, Mehrian-Shai R, Chakrabarty P, Torres Jimenez MF, "Beyond DNA: The rest of the story". Science. 371 (6529), 560-563, 2021. Article, In "Human Genome at 20" Special Issue
25. Morgan LE#, Jaramillo AM#, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ , El-Batal HM, Magin CM, Grove Villalon DE, Duncan GA, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. “Disulfide disruption reverses mucus dysfunction in allergic airway disease”. Nature Communications. 12 (249), 2021. Article, Preprint
24. Linssen RS, Chai G, Ma J, Kummarapurugu A, van Woensel JBM, Bem RA, Kaler L, Duncan GA, Zhou L, Rubin BK, Xu Q. “Neutrophil extracellular traps increase airway mucus viscoelasticity and impede particle transit through the mucus layer”. American Journal of Respiratory Cell and Molecular Biology. 64 (1), 69-78, 2021. Article
23. Joyner K, Yang S, Duncan GA. "Microrheology for biomaterial design". APL Bioengineering. 4, 041508, 2020. Article, Selected as a Featured Article
22. Iverson E, Kaler L, Agostino EL, Song D, Duncan GA, Scull MA. “Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa”. Viruses. 12 (12), 1425, 2020. Article, In "Application of 3D Tissue Culture Systems in Virology" Special Issue
21. Hawkins RF, Duncan GA. “Plate reader microrheology”. AIP Advances, 10, 115312, 2020. Article, Preprint
20. Song D, Cahn D, Duncan GA. “Mucin biopolymers and their barrier function at airway surfaces”. Langmuir, 36 (43), 12773–12783, 2020. Invited Feature Article, Selected as ACS Editor's Choice
19. Joyner K, Song D, Hawkins R, Silcott R, Duncan GA. “A rational approach to form disulfide-linked mucin hydrogels”. Soft Matter. 15, 9632-9639, 2019. Article, Featured on Back Cover, Preprint
18. Joyner K, Duncan GA. “Reliably Sourced Airway Mucus”. American Journal of Physiology: Lung Cellular and Molecular Physiology. 317(4), pp. L496–L497. 2019. Article
17. Segal L, Agarwal D, Isaacson KJ, Oehmke TB, Kumar B, Chen JS, Cusimano JM, Negi S, Tiper I, Bakermans AJ, Jensen MM, Sanganyado E, Zaidi SS, Romero-Molina C, Martínez SE, Anderson SM, Santos GM, De Lella Ezcurra AL, Farragher J, Sharma V, Duncan G, Dutton-Regester K, Kim SA, Yu S, Schwendimann BA, Reichardt JKV, Halder A, Dennis AF, Ellwanger JH, Chiu YH, Kerman BE. "NextGen Voices: Quality mentoring." Science. 362 (6410):22-24. 2018. Article
16. Osman G, Rodriguez J, Chan SY, Chisholm J, Duncan GA, Kim N, Tatler AL, Shakesheff KM, Hanes J, Suk JS, Dixon JE. “PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy”. Journal of Controlled Release. 285, 35-45, 2018. Article
15. Lu HD, Pearson E, Ristroph KD, Duncan GA, Ensign LM, Suk JS, Hanes J, Prud'homme RK. ”Pseudomonas aeruginosa Pyocyanin Production Reduced by Quorum-Sensing Inhibiting Nanocarriers”. International Journal of Pharmaceutics. 544(1), 75-82, 2018. Article
14. Duncan GA, Kim N, Colon-Cortes Y, Rodriguez J, Mazur M, Birket SE, Rowe SM, West NE, Livraghi-Butrico A, Boucher RC, Hanes J, Aslanidi G, Suk JS. “An adeno-associated viral vector capable of penetrating the mucus barrier to inhaled gene therapy”. Molecular Therapy: Methods & Clinical Development. 9, 296-304, 2018. Article
13. Patil H, Freches D, Karmani L, Duncan GA, Ucakar B, Suk JS, Hanes J, Gallez B, Van Bever R. “Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation”. Journal of Controlled Release. 272, 62-71, 2018. Article
12. Bitter J, Yang Y, Duncan GA, Fairbrother DH, Bevan MA. "Interfacial & Confined Colloidal Rod Diffusion". Langmuir, 33(36), 9034-42, 2017. Article
11. Huang X, Chisholm J, Zhuang J, Xiao Y, Duncan GA, Chen X, Suk JS, Hanes J. “Protein Nanocages that Penetrate Airway Mucus and Tumor Tissue“. Proceedings of the National Academy of Sciences, 114(32), E6595-E6602, 2017. Article
10. Duncan GA, Jung J, Hanes J, Suk JS. “The Mucus Barrier to Inhaled Gene Therapy”. Molecular Therapy. 24(12), 2043-53, 2016. Article
9. Duncan GA, Jung J, Joseph A, Thaxton AL, West NE, Boyle MP, Hanes J, Suk JS. “Microstructural Alterations of Sputum in Cystic Fibrosis Lung Disease”. JCI Insight, 1(18), e88198, 2016. Article
8. Kim N, Duncan GA, Hanes J*, Suk JS*. “Barriers to inhaled gene therapy of obstructive lung diseases: A review”. Journal of Controlled Release. 240, 465–488, 2016. Article
7. Duncan GA, Lockett A, Villegas LR, Almodovar S, Gomez JL, Flores SC, Wilkes DS, Tigno, XT. “National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce”. Annals of American Thoracic Society, 13(4), 562-67, 2016. Article
6. Duncan GA, Gerecht S, Fairbrother DH, Bevan MA. “Diffusing Colloidal Probes of kT-scale Biomaterial-Cell Interactions”. Langmuir. 32(46), 12212-20, 2016. Article
5. Duncan GA, Fairbrother DH, Bevan MA. “Diffusing Colloidal Probes of Cell Surfaces”. Soft Matter, 12(21), 4731-8, 2016. Article
4. Duncan GA, Bevan MA. “Computational Design of Nanoparticle Drug Delivery Systems for Selective Targeting”. Nanoscale, 7(37), 15332-40, 2015. Article
3. Duncan GA, Bevan MA. “Tunable Aggregation By Competitive Biomolecular Interactions”. Langmuir, 30(50), 15253-60, 2014. Article
2. Duncan GA, Bevan MA. “Colloidal Potentials Mediated by Biomolecular Interactions”. Soft Matter, 10(42), 8524-32, 2014. Article
1. Bitter JL, Duncan GA, Beltran-Villegas DJ, Fairbrother DH, Bevan MA. “Anomalous Silica Colloid Stability and Gel Layer Mediated Interactions”. Langmuir, 29(28), 8835-44, 2013. Article
42. Zou H, Boboltz A, Cheema Y, Song D, Cahn D, Duncan GA. “Synthetic mucus barrier arrays as a nanoparticle formulation screening platform”. RSC Pharmaceutics. 1, 218–226, 2024. Article, Preprint
41. Boboltz A, Yang S, Duncan GA. “Engineering in vitro models of cystic fibrosis lung disease using neutrophil extracellular trap inspired biomaterials”. Journal of Materials Chemistry B. 11, 9419-9430, 2023. Article, Preprint, Featured on Cover, Invited for "Biomaterials in Innate Immunity" themed collection
40. Yang S, Duncan GA. "Synthetic mucus biomaterials for antimicrobial peptide delivery." Journal of Biomedical Materials Research: Part A. 111 (10), 1616-26, 2023. Article, Preprint
39. Boboltz A, Kumar S, Duncan GA. “Inhaled drug delivery for the targeted treatment of asthma”. Advanced Drug Delivery Reviews. 98, 114858, 2023. Article, Selected for Emerging Voices in Drug Delivery Special Issue
38. Yeruva T, Yang S, Doski S, Duncan GA. “Hydrogels for Mucosal Drug Delivery”. ACS Applied Bio Materials. 6 (5), 1684–1700, 2023. Article
37. Zhang Y, Li S, Loch K, Duncan GA, Kaler L, Pangeni R, Peng W, Wang S, Gong X, Xu Q . “pH-responsive Mucus-penetrating Nanoparticles for Enhanced Cellular Internalization by Local Administration in Vaginal Tissue”. ACS Macro Letters. 12 (4), 446–453, 2023. Article
36. Cahn D, Amosu M, Maisel K, Duncan GA. “Biomaterials for intranasal and inhaled vaccine delivery”. Nature Reviews Bioengineering. 1, 83–84, 2023. Article
35. Song D, Iverson E, Kaler L, Boboltz A, Scull MA, Duncan GA. “MUC5B mobilizes and MUC5AC spatially aligns mucociliary transport on human airway epithelium”. Science Advances. 8, eabq504, 2022. Article, Preprint
34. Cahn D, Duncan GA. "High-Density Branched PEGylation for Nanoparticle Drug Delivery". Cellular and Molecular Bioengineering. 15, 355–366, 2022. Article, Selected for Young Innovators Special Issue
33. Kaler L, Joyner K, Duncan GA. "Machine Learning Informed Prediction of Nanoparticle Mobility and Fate in the Mucus Barrier". APL Bioengineering. 6, 026103, 2022. Article, Preprint
32. Iverson E, Griswold K, Song D, Gagliardi TB, Hamidzadeh K, Kesimer M, Sinha S, Perry M, Duncan GA, Scull MA. “Membrane-Tethered Mucin 1 is Stimulated by Interferon in Multiple Cell Types and Antagonizes Influenza A Virus Infection in Human Airway Epithelium”. mBio. e01055-22, 2022. Article, Preprint
31. Kaler L, Iverson E, Bader S, Song D, Scull MA, Duncan GA. “Influenza A virus diffusion through mucus gel networks". Communications Biology, 5 (249), 2022. Article, Preprint
30. Gagliardi TB, Goldstein ME, Song D, Gray KM, Jung J, Ignacio M, Stroka K, Duncan GA, Scull MA. “Rhinovirus C replication is associated with the endoplasmic reticulum and triggers cytopathic effects in an in vitro model of human airway epithelium”. PLOS Pathogens. 18(1), e1010159, 2022. Article, Preprint, Featured on Cover
29. Duncan GA. "Integrative approaches to enhance adeno-associated viral gene delivery". Journal of Controlled Release. 341, 44-50, 2022. Article
28. Lee BJ, Cheema Y, Bader S, Duncan GA. “Shaping nanoparticle diffusion through biological barriers to drug delivery”. JCIS Open, 100025, 2021. Article, Preprint
27. Song D, Iverson E, Kaler L, Bader S, Scull MA, Duncan GA. “Modeling airway dysfunction in asthma using synthetic mucus biomaterials”. ACS Biomaterials Science & Engineering. 7 (6), 2723–33, 2021. Article, Preprint
26. Duncan GA, J Yongsheng, Lefort MC, Mehrian-Shai R, Chakrabarty P, Torres Jimenez MF, "Beyond DNA: The rest of the story". Science. 371 (6529), 560-563, 2021. Article, In "Human Genome at 20" Special Issue
25. Morgan LE#, Jaramillo AM#, Shenoy SK, Raclawska D, Emezienna NA, Richardson VL, Hara N, Harder AQ , El-Batal HM, Magin CM, Grove Villalon DE, Duncan GA, Hanes JS, Suk JS, Thornton DJ, Holguin F, Janssen WJ, Thelin WR, Evans CM. “Disulfide disruption reverses mucus dysfunction in allergic airway disease”. Nature Communications. 12 (249), 2021. Article, Preprint
24. Linssen RS, Chai G, Ma J, Kummarapurugu A, van Woensel JBM, Bem RA, Kaler L, Duncan GA, Zhou L, Rubin BK, Xu Q. “Neutrophil extracellular traps increase airway mucus viscoelasticity and impede particle transit through the mucus layer”. American Journal of Respiratory Cell and Molecular Biology. 64 (1), 69-78, 2021. Article
23. Joyner K, Yang S, Duncan GA. "Microrheology for biomaterial design". APL Bioengineering. 4, 041508, 2020. Article, Selected as a Featured Article
22. Iverson E, Kaler L, Agostino EL, Song D, Duncan GA, Scull MA. “Leveraging 3D Model Systems to Understand Viral Interactions with the Respiratory Mucosa”. Viruses. 12 (12), 1425, 2020. Article, In "Application of 3D Tissue Culture Systems in Virology" Special Issue
21. Hawkins RF, Duncan GA. “Plate reader microrheology”. AIP Advances, 10, 115312, 2020. Article, Preprint
20. Song D, Cahn D, Duncan GA. “Mucin biopolymers and their barrier function at airway surfaces”. Langmuir, 36 (43), 12773–12783, 2020. Invited Feature Article, Selected as ACS Editor's Choice
19. Joyner K, Song D, Hawkins R, Silcott R, Duncan GA. “A rational approach to form disulfide-linked mucin hydrogels”. Soft Matter. 15, 9632-9639, 2019. Article, Featured on Back Cover, Preprint
18. Joyner K, Duncan GA. “Reliably Sourced Airway Mucus”. American Journal of Physiology: Lung Cellular and Molecular Physiology. 317(4), pp. L496–L497. 2019. Article
17. Segal L, Agarwal D, Isaacson KJ, Oehmke TB, Kumar B, Chen JS, Cusimano JM, Negi S, Tiper I, Bakermans AJ, Jensen MM, Sanganyado E, Zaidi SS, Romero-Molina C, Martínez SE, Anderson SM, Santos GM, De Lella Ezcurra AL, Farragher J, Sharma V, Duncan G, Dutton-Regester K, Kim SA, Yu S, Schwendimann BA, Reichardt JKV, Halder A, Dennis AF, Ellwanger JH, Chiu YH, Kerman BE. "NextGen Voices: Quality mentoring." Science. 362 (6410):22-24. 2018. Article
16. Osman G, Rodriguez J, Chan SY, Chisholm J, Duncan GA, Kim N, Tatler AL, Shakesheff KM, Hanes J, Suk JS, Dixon JE. “PEGylated enhanced cell penetrating peptide nanoparticles for lung gene therapy”. Journal of Controlled Release. 285, 35-45, 2018. Article
15. Lu HD, Pearson E, Ristroph KD, Duncan GA, Ensign LM, Suk JS, Hanes J, Prud'homme RK. ”Pseudomonas aeruginosa Pyocyanin Production Reduced by Quorum-Sensing Inhibiting Nanocarriers”. International Journal of Pharmaceutics. 544(1), 75-82, 2018. Article
14. Duncan GA, Kim N, Colon-Cortes Y, Rodriguez J, Mazur M, Birket SE, Rowe SM, West NE, Livraghi-Butrico A, Boucher RC, Hanes J, Aslanidi G, Suk JS. “An adeno-associated viral vector capable of penetrating the mucus barrier to inhaled gene therapy”. Molecular Therapy: Methods & Clinical Development. 9, 296-304, 2018. Article
13. Patil H, Freches D, Karmani L, Duncan GA, Ucakar B, Suk JS, Hanes J, Gallez B, Van Bever R. “Fate of PEGylated antibody fragments following delivery to the lungs: Influence of delivery site, PEG size and lung inflammation”. Journal of Controlled Release. 272, 62-71, 2018. Article
12. Bitter J, Yang Y, Duncan GA, Fairbrother DH, Bevan MA. "Interfacial & Confined Colloidal Rod Diffusion". Langmuir, 33(36), 9034-42, 2017. Article
11. Huang X, Chisholm J, Zhuang J, Xiao Y, Duncan GA, Chen X, Suk JS, Hanes J. “Protein Nanocages that Penetrate Airway Mucus and Tumor Tissue“. Proceedings of the National Academy of Sciences, 114(32), E6595-E6602, 2017. Article
10. Duncan GA, Jung J, Hanes J, Suk JS. “The Mucus Barrier to Inhaled Gene Therapy”. Molecular Therapy. 24(12), 2043-53, 2016. Article
9. Duncan GA, Jung J, Joseph A, Thaxton AL, West NE, Boyle MP, Hanes J, Suk JS. “Microstructural Alterations of Sputum in Cystic Fibrosis Lung Disease”. JCI Insight, 1(18), e88198, 2016. Article
8. Kim N, Duncan GA, Hanes J*, Suk JS*. “Barriers to inhaled gene therapy of obstructive lung diseases: A review”. Journal of Controlled Release. 240, 465–488, 2016. Article
7. Duncan GA, Lockett A, Villegas LR, Almodovar S, Gomez JL, Flores SC, Wilkes DS, Tigno, XT. “National Heart, Lung, and Blood Institute Workshop Summary: Enhancing Opportunities for Training and Retention of a Diverse Biomedical Workforce”. Annals of American Thoracic Society, 13(4), 562-67, 2016. Article
6. Duncan GA, Gerecht S, Fairbrother DH, Bevan MA. “Diffusing Colloidal Probes of kT-scale Biomaterial-Cell Interactions”. Langmuir. 32(46), 12212-20, 2016. Article
5. Duncan GA, Fairbrother DH, Bevan MA. “Diffusing Colloidal Probes of Cell Surfaces”. Soft Matter, 12(21), 4731-8, 2016. Article
4. Duncan GA, Bevan MA. “Computational Design of Nanoparticle Drug Delivery Systems for Selective Targeting”. Nanoscale, 7(37), 15332-40, 2015. Article
3. Duncan GA, Bevan MA. “Tunable Aggregation By Competitive Biomolecular Interactions”. Langmuir, 30(50), 15253-60, 2014. Article
2. Duncan GA, Bevan MA. “Colloidal Potentials Mediated by Biomolecular Interactions”. Soft Matter, 10(42), 8524-32, 2014. Article
1. Bitter JL, Duncan GA, Beltran-Villegas DJ, Fairbrother DH, Bevan MA. “Anomalous Silica Colloid Stability and Gel Layer Mediated Interactions”. Langmuir, 29(28), 8835-44, 2013. Article
Preprints
4. Yeruva T, Morris III RJ, Zhao L, Kofinas P, Duncan GA. “Rapid in situ forming PEG hydrogels for mucosal drug delivery”. bioRxiv. 2024. Preprint
3. Yang S, Stern A, Duncan GA. “Synthetic mucus biomaterials synergize with antibiofilm agents to combat Pseudomonas aeruginosa biofilm”. bioRxiv. 2024. Preprint
2. Cahn D, Stern A, Buckenmeyer MJ, Wolf M, Duncan GA. “The Extracellular Matrix Limits Nanoparticle Diffusion and Cellular Uptake in a Tissue-Specific Manner”. bioRxiv. 2024. Preprint
1. Kaler L, Engle EM, Iverson E S, Boboltz A, Ignacio MA, Rife M, Scull MA, Duncan GA. “Mucus physically restricts influenza A viral particle access to the epithelium”. bioRxiv. 2023. Preprint
3. Yang S, Stern A, Duncan GA. “Synthetic mucus biomaterials synergize with antibiofilm agents to combat Pseudomonas aeruginosa biofilm”. bioRxiv. 2024. Preprint
2. Cahn D, Stern A, Buckenmeyer MJ, Wolf M, Duncan GA. “The Extracellular Matrix Limits Nanoparticle Diffusion and Cellular Uptake in a Tissue-Specific Manner”. bioRxiv. 2024. Preprint
1. Kaler L, Engle EM, Iverson E S, Boboltz A, Ignacio MA, Rife M, Scull MA, Duncan GA. “Mucus physically restricts influenza A viral particle access to the epithelium”. bioRxiv. 2023. Preprint
Patents
1. Duncan GA, Joyner K, Song D, Hawkins R. “Synthetic, mucus-like hydrogel and method of preparation, and system and method for performing microrheology on hydrogels and other complex fluids”. US Patent App. (Pending), 16/945,830, 2021. Link